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Expression and processing of the TMEM70 protein
- 1.0359610 - FGÚ 2012 RIV NL eng J - Journal Article
Hejzlarová, Kateřina - Tesařová, M. - Vrbacká-Čížková, A. - Vrbacký, Marek - Hartmannová, H. - Kaplanová, Vilma - Nosková, L. - Kratochvílová, H. - Buzková, J. - Havlíčková, Vendula - Zeman, J. - Kmoch, S. - Houštěk, Josef
Expression and processing of the TMEM70 protein.
Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1807, č. 1 (2011), s. 144-149. ISSN 0005-2728. E-ISSN 1879-2650
R&D Projects: GA MZd(CZ) NS9759; GA MŠMT(CZ) 1M0520; GA ČR(CZ) GAP303/11/0970
Grant - others:UK(CZ) 259089; UK(CZ) 56209; UK(CZ) 37710
Institutional research plan: CEZ:AV0Z50110509
Keywords : mitochondria * ATP synthase * TMEM70 * biogenesis * import
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.843, year: 2011
Characterization of TMEM70 protein, the novel ancillary factor of mammalian ATP synthase revealed that it is synthesized as a 29 kDa precursor that is processed to mature 21 kDa form upon import to mitochondria. TMEM70 is located in the inner mitochondrial membrane, as a monomer and dimer. Cellular content and expression of TMEM70 is very low and it is absent in patients with ATP synthase deficiency due to TMEM70 c.317-2A>G mutation
Permanent Link: http://hdl.handle.net/11104/0197366
Number of the records: 1