0359445 - FGÚ 2012 RIV US eng J - Journal Article
Pravenec, Michal - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, J. - Maxová, M. - Kazdová, L. - Seidman, J. G. - Seidman, Ch. E. - Eminaga, S. - Gorham, J. - Wang, J. - Kurtz, T. W.
Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.
Physiological Genomics. Roč. 43, č. 7 (2011), s. 372-379. ISSN 1094-8341. E-ISSN 1531-2267
R&D Projects: GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0510; GA AV ČR(CZ) IAA500110805; GA MZd(CZ) NS9759
Grant - others:Fondation Leducq(FR) 06CVD03
Institutional research plan: CEZ:AV0Z50110509
Keywords : transgenic rat * adipose tissue * insulin resistance * autocrine effects
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 2.735, year: 2011 ; AIS: 1.126, rok: 2011
DOI: https://doi.org/10.1152/physiolgenomics.00112.2010

We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue
Permanent Link: http://hdl.handle.net/11104/0197234