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Real/time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor
- 1.0350305 - ÚFE 2011 RIV DE eng J - Journal Article
Špringer, Tomáš - Piliarik, Marek - Homola, Jiří
Real/time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor.
Analytical and Bioanalytical Chemistry. Roč. 398, č. 5 (2010), s. 1955-1961. ISSN 1618-2642. E-ISSN 1618-2650
R&D Projects: GA AV ČR KAN200670701; GA MŠMT OC09058
Institutional research plan: CEZ:AV0Z20670512
Keywords : surface plasmon resonance * molecular interaction analysis * microfluidics * optical biosensor
Subject RIV: BO - Biophysics
Impact factor: 3.841, year: 2010
We report a novel biosenor approach which enables real-time monitoring of biomolecular interactions in complex samples. This approach is demonstrated by investigating model interaction between the human chorionic gonadotropin and its antibody in blood plasma using a surface plasmon resonance biosensor and a novel dispersionless microfluidics. The proposed approach also significantly enhance capability of the biosensor to detect biomolecules in complex samples in terms of detection time and sensitivity.
Permanent Link: http://hdl.handle.net/11104/0190340
Number of the records: 1