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Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase
- 1.0332733 - ÚOCHB 2010 RIV US eng J - Journal Article
Urban, M. - Joubert, Nicolas - Hocek, Michal - Alexander, R. E. - Kuchta, R. D.
Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase.
Biochemistry. Roč. 48, č. 46 (2009), s. 10866-10881. ISSN 0006-2960
R&D Projects: GA MŠMT LC512; GA AV ČR IAA400550902
Grant - others:NIH(US) AI059764
Institutional research plan: CEZ:AV0Z40550506
Keywords : HSV-1 * herpes simplex virus-1 * Pyr * pyrimidine
Subject RIV: CC - Organic Chemistry
Impact factor: 3.226, year: 2009
The study showed that HSV-1 primase does not need Watson-Crick base pairing for efficient incorporation of nucleotides. It misincorporates nucleotides both by misreading of template and by primer-template splippage mechanism.
Permanent Link: http://hdl.handle.net/11104/0177890
Number of the records: 1