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Muscarinic Transmission is Impaired in Zouny Adult Transgenic APPswe/PS1dE9 Female Mice
- 1.0311242 - FGÚ 2009 RIV IT eng C - Conference Paper (international conference)
Machová, Eva - Jakubík, Jan - Michal, Pavel - Oksman, M. - Iivonen, H. - Tanila, H. - Doležal, Vladimír
Muscarinic Transmission is Impaired in Zouny Adult Transgenic APPswe/PS1dE9 Female Mice.
[Muskarinová neurotransmise je zhoršena u mladých dospělých samic APPswe/PS1dE9 myši.]
New Trends in Alzenheimer and Parkinson Related Disorders. Bologna: Mediamond, 2007 - (Hanin, I.; Windisch, M.; Poewe, W.), s. 91-94. ISBN 978-88-7587-405-6.
[International conference Alzheimer´s diseases/Parkinson´s diseases /8./. Salzburg (AT), 14.03.2007-18.03.2007]
R&D Projects: GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA500110703
Grant - others:EC(XE) QLK1-CT-2002-00172
Institutional research plan: CEZ:AV0Z50110509
Keywords : Alzheimer´s disease * muscarinic receptors * cholinergic neurotransmission
Subject RIV: FH - Neurology
We have investigated cholinergic neurotransmission markers in young adult and aged APPswe/PS1dE9 female mice. We found both age and transgen dependent changes. The most important change is impairment of muscarinic receptor-mediated signaling in young transgenic mice
Sledovali jsme markery cholinergní neurotransmise samic mladých dospělých a starých APPswe/PS1dE9 myší. Našli jsme změny závislé jak na věku tak i na přítomnosti transgenu. Zvláště závažné je narušení přenosu signálu mezi muskarinovými receptory a G-proteiny
Permanent Link: http://hdl.handle.net/11104/0162912
Number of the records: 1