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Modulation of Radioprotective Effects of Respiratory Hypoxia by Changing the Duration of Hypoxia before Irradiation and by Combining Hypoxia and Administration of Hemopoiesis-Stimulating Agents
- 1.0126471 - BFU-R 20013031 RIV DE eng J - Journal Article
Vacek, Antonín - Tačev, T. - Hofer, Michal
Modulation of Radioprotective Effects of Respiratory Hypoxia by Changing the Duration of Hypoxia before Irradiation and by Combining Hypoxia and Administration of Hemopoiesis-Stimulating Agents.
Strahlentherapie Und Onkologie. Roč. 177, č. 9 (2001), s. 474-481. ISSN 0179-7158. E-ISSN 1439-099X
Institutional research plan: CEZ:AV0Z5004920
Keywords : radioprotection * mice * hypoxia
Subject RIV: BO - Biophysics
Impact factor: 3.005, year: 2001
Radioprotective effects of respiratory hypoxia on hematopoiesis and possibilities of enhancing these effects by granulocyte-macrophage colony-stimulating factor or dextran sulfate were analysed in gamma-irradiated mice. Hypoxia improved the recovery of hematopoiesis and mitigated lethal effects of gamma-rays. Enhancement of proliferative activity in hematopoietic tissues by hematopoietic stimulators increased the radioprotective effects of hypoxia. Adaptation of experimental animals to hypoxic conditions was found to reduce the radioprotective effects without influencing tissue partial oxygen pressure lowered by hypoxia
Permanent Link: http://hdl.handle.net/11104/0024700
Number of the records: 1