Gliadin stimulates human monocytes to production of IL-8 and TNF-alfa through a mechanism involving NF-kB

0107934 - MBU-M 20040140 RIV NL eng J - Journal Article
Palová-Jelínková, Lenka - Tučková, Ludmila - Cinová, Jana - Flegelová, Z. - Tlaskalová, Helena
Gliadin stimulates human monocytes to production of IL-8 and TNF-alfa through a mechanism involving NF-kB.
[Gliadin stimuluje lidské monocyty k tvorbě IL-8 a TNF-a mechanismem zahrnujícím NF-kB.]
FEBS Letters. Roč. 571, - (2004), s. 81-85. ISSN 0014-5793. E-ISSN 1873-3468
R&D Projects: GA ČR GA310/02/1470; GA ČR GD310/03/H147; GA ČR GP310/04/P242; GA AV ČR IAA5020210; GA AV ČR IAA5020205; GA AV ČR IBS5020203; GA AV ČR KJB5020407
Institutional research plan: CEZ:AV0Z5020903
Keywords : monocyte * gliadin * interleukin-8
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.843, year: 2004

Proteolytic fragments of gliadin, in contrast to other food antigens, induce IL-8 and TNF-a production in human monocytic cell line THP-1. The activation pathway was shown to be mediated via NFkB.

Proteolytické štěpy gliadinu stimulují lidské monocýtární buňky THP-1k produkci IL-8 a TNF-a. Signalizační dráha zahrnuje NFkB molekulární komplex.
Permanent Link: http://hdl.handle.net/11104/0015074