Number of the records: 1
Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine
- 1.0024057 - FGÚ 2006 RIV US eng J - Journal Article
Svobodová, Lucie - Krůšek, Jan - Hendrych, Tomáš - Vyskočil, František
Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine.
[Alosterická modulace nikotinického acetylcholinového receptoru physostigminem.]
New York Academy of Sciences. Annals. Roč. 1048, - (2005), s. 355-358. ISSN 0077-8923. E-ISSN 1749-6632
R&D Projects: GA ČR(CZ) GA202/02/1213; GA ČR(CZ) GA305/02/1333; GA ČR(CZ) GD305/03/H148
Institutional research plan: CEZ:AV0Z5011922
Keywords : nicotinic ACh receptor * serine * desensitization
Subject RIV: ED - Physiology
Impact factor: 1.971, year: 2005
The action of physostigmine on mouse nicotinic acetylcholine receptor expressed in the COS–7 cell line was studiem by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rat of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner
Metodou terčíkového zámku (patch-clamp) byly studovány účinky physostigminu na myší svalové nikotinické acetylcholinové receptory exprimované v linii COS–7 buněk. Physostigmin alosterickým mechanismem urychloval desentizaci a snižoval velikost proudů vyvolaných aplikací acetylcholinu
Permanent Link: http://hdl.handle.net/11104/0114662
Number of the records: 1