Počet záznamů: 1

Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats

  1. 1.
    0370179 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Alán, Lukáš - Špaček, Tomáš - Zelenka, Jaroslav - Tauber, Jan - Berková, Z. - Zacharovová, K. - Saudek, F. - Ježek, Petr
    Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats.
    Transplantation Proceedings. Roč. 43, č. 9 (2011), s. 3281-3284 ISSN 0041-1345.
    [World Congress of the International Pancreas and Islet Transplant Association /13./. Praha, 01.06.2011-04.06.2011]
    Grant CEP: GA MZd NS10219
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: type 2 diabetes * mtDNA * beta-cells
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 1.005, rok: 2011

    Diabetic Goto Kakizaki (GK) rats represent an established model of type 2 diabetes that exhibit an onset of pancreatic islet (PI) pathology characterized by islet hypertrophy with decreased number of insulin-secreting beta-cells. Among the remaining beta-cells, oxidative phosphorylation (OXPHOS) and consequently glucose-stimulated insulin secretion (GSIS) are impaired, perhaps owing to a deficit in mitochondrial DNA (mtDNA). We measured content of mtDNA compared to Wistar rats in different tissues and we found drastic decrease in number of mtDNA
    Trvalý link: http://hdl.handle.net/11104/0204053