Počet záznamů: 1

Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148

  1. 1.
    0370118 - UMG-J 2012 RIV US eng J - Článek v odborném periodiku
    Štěpánek, Ondřej - Kalina, T. - Dráber, Peter - Skopcová, Tereza - Svojgr, K. - Angelisová, Pavla - Hořejší, Václav - Weiss, A. - Brdička, Tomáš
    Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.
    Journal of Biological Chemistry. Roč. 286, č. 25 (2011), s. 22101-22112 ISSN 0021-9258
    Grant CEP: GA MŠk 2B06064; GA MŠk 1M0506
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: CD148 * tyrosine phosphatase * Src family kinases
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.773, rok: 2011

    CD148 is a receptor-like protein-tyrosine phosphatase inhibiting transduction of signals in non-hematopoietic cells. We describe striking differences in CD148 expression between human and murine thymocyte subsets, the only unifying feature being the absence of CD148 during the positive selection when the major developmental block occurs under CD45 deficiency. CD148 has both activating and inhibitory effects on the SFKs involved in TCR signaling. In the absence of CD45, activating effects prevail, resulting in functional complementation of CD45 deficiency in human T cell lines. This is independent of the tyrosines in the CD148 C-terminal tail, contradicting the recently proposed phosphotyrosine displacement model as a mechanism of SFK activation by CD148. Differential effects of CD148 in T cells and other leukocyte subsets cannot be explained by the CD148 inability to activate T cell SFKs but rather by its dual inhibitory/activatory function and specific expression pattern.
    Trvalý link: http://hdl.handle.net/11104/0204013
    Název souboruStaženoVelikostKomentářVerzePřístup
    0370118.pdf32.8 MBVydavatelský postprintvyžádat