Počet záznamů: 1

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

  1. 1.
    0370088 - MBU-M 2012 RIV CN eng J - Článek v odborném periodiku
    Tlaskalová-Hogenová, Helena - Štěpánková, Renata - Kozáková, Hana - Hudcovic, Tomáš - Vannucci, Luca - Tučková, Ludmila - Rossmann, Pavel - Hrnčíř, Tomáš - Kverka, Miloslav - Zákostelská, Zuzana - Klimešová, Klára - Přibylová, Jaroslava - Bártová, J. - Sánchez, Daniel - Fundová, P. - Borovská, Dana - Šrůtková, Dagmar - Zídek, Zdeněk - Schwarzer, Martin - Drastich, P. - Funda, David P.
    The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.
    Cellular & Molecular Immunology. Roč. 8, č. 2 (2011), s. 110-120 ISSN 1672-7681
    Grant CEP: GA ČR GA303/08/0367; GA ČR GA303/09/0449; GA ČR GA310/07/0414; GA ČR GA305/08/0535; GA ČR GA310/09/1640; GA ČR GD310/08/H077; GA AV ČR IAA500200710; GA AV ČR KJB500200904; GA AV ČR IAA500200917; GA AV ČR IAA500200709; GA MŠk 2B06053; GA MŠk 2B06155; GA MZd NS9775; GA MZd NS10054; GA MZd(CZ) NS10340; GA MŠk 7E09091
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50390512
    Klíčová slova: allergy * hygiene hypothesis * intestinal permeability
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 2.992, rok: 2011

    Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization. Animals used as models of human diseases can be maintained in sterile conditions (isolators used for germ-free rearing) and specifically colonized with defined microbes (including non-cultivable commensal bacteria). The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models. Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia (i.e., using models of human inflammatory bowel disease and colorectal carcinoma
    Trvalý link: http://hdl.handle.net/11104/0203992