Počet záznamů: 1

SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling

  1. 1.
    0370084 - UMG-J 2012 RIV US eng J - Článek v odborném periodiku
    Dráber, Peter - Vonková, Ivana - Štěpánek, Ondřej - Hrdinka, Matouš - Kucová, Markéta - Skopcová, Tereza - Otáhal, Pavel - Angelisová, Pavla - Hořejší, Václav - Yeung, M. - Weiss, A. - Brdička, Tomáš
    SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
    Molecular and Cellular Biology. Roč. 31, č. 22 (2011), s. 4550-4562 ISSN 0270-7306
    Grant CEP: GA MŠk 1M0506; GA ČR GEMEM/09/E011
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: SCIMP * transmembrane adaptor protein * MHC II
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.527, rok: 2011

    The discovery of a new palmitoylated transmembrane adaptor protein, termed SCIMP, is described. SCIMP is expressed in B cells and other professional APCs and is localized in the immunological synapse due to its association with tetraspanin-enriched microdomains. In B cells, it is constitutively associated with Lyn kinase and becomes tyrosine phosphorylated after major histocompatibility complex type II (MHC-II) stimulation. When phosphorylated, SCIMP binds to the SLP65 adaptor protein and also to the inhibitory kinase Csk. While the association with SLP65 initiates the downstream signaling cascades, Csk binding functions as a negative regulatory loop. The results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions.
    Trvalý link: http://hdl.handle.net/11104/0203989
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