Počet záznamů: 1

Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

  1. 1.
    0369985 - UOCHB-X 2013 RIV CZ eng J - Článek v odborném periodiku
    Dejmek, Milan - Hřebabecký, Hubert - Dračínský, Martin - Neyts, J. - Leyssen, P. - Mertlíková-Kaiserová, Helena - Nencka, Radim
    Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties.
    Collection of Czechoslovak Chemical Communications. Roč. 76, č. 12 (2011), s. 1549-1566 ISSN 0010-0765
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: 1'-homonucleosides * Diels-Alder reaction * antiviral agents
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.283, rok: 2011

    We report on the preparation of novel 1’-homonucleoside derivatives locked in a West conformation by 1’,4’-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels-Alder reaction of an appropriate aryne with a suitable furane derivative. Antiviral properties of novel compounds were studied and slight activity against HCV was detected in several compounds.
    Trvalý link: http://hdl.handle.net/11104/0203913