Počet záznamů: 1
Crystal structure of a monomeric retroviral protease solved by protein folding game players
0369853 - UOCHB-X 2012 RIV US eng J - Článek v odborném periodiku
Khatíb, F. - Dímaio, F. - Cooper, S. - Kazmierczyk, M. - Gilski, M. - Krzywda, S. - Zábranská, Helena - Pichová, Iva - Thompson, J. - Popovic, Z. - Jaskolski, M. - Baker, D.
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Nature Structural and Molecular Biology. Roč. 18, č. 10 (2011), s. 1175-1177 ISSN 1545-9985
Grant CEP: GA MŠk 1M0508
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: M-MPV protease * monomer * model * Foldit
Kód oboru RIV: CE - Biochemie
Impakt faktor: 13.685, rok: 2010
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
Trvalý link: http://hdl.handle.net/11104/0203824