Počet záznamů: 1

Crystal structure of a monomeric retroviral protease solved by protein folding game players

  1. 1.
    0369853 - UOCHB-X 2012 RIV US eng J - Článek v odborném periodiku
    Khatíb, F. - Dímaio, F. - Cooper, S. - Kazmierczyk, M. - Gilski, M. - Krzywda, S. - Zábranská, Helena - Pichová, Iva - Thompson, J. - Popovic, Z. - Jaskolski, M. - Baker, D.
    Crystal structure of a monomeric retroviral protease solved by protein folding game players.
    Nature Structural and Molecular Biology. Roč. 18, č. 10 (2011), s. 1175-1177 ISSN 1545-9985
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: M-MPV protease * monomer * model * Foldit
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 13.685, rok: 2010

    Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
    Trvalý link: http://hdl.handle.net/11104/0203824