Počet záznamů: 1

4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics

  1. 1.
    0369807 - UOCHB-X 2012 RIV GB eng J - Článek v odborném periodiku
    Liboska, Radek - Snášel, Jan - Barvík, I. - Buděšínský, Miloš - Pohl, Radek - Točík, Zdeněk - Páv, Ondřej - Rejman, Dominik - Novák, Pavel - Rosenberg, Ivan
    4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.
    Organic & Biomolecular Chemistry. Roč. 9, č. 24 (2011), s. 8261-8267 ISSN 1477-0520
    Grant CEP: GA ČR GA202/09/0193; GA AV ČR KAN200520801; GA MŠk(CZ) LC06061
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: 4'-alkoxy oligothymidylates * modified oligonucleotides * oligonucleotide hybridisation * RNA mimics
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.696, rok: 2011

    4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties.
    Trvalý link: http://hdl.handle.net/11104/0203789