Počet záznamů: 1

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

  1. 1.
    0369496 - BTO-N 2012 RIV US eng J - Článek v odborném periodiku
    Neužil, Jiří - Černý, Jiří - Dyason, J.C. - Dong, L.-F. - Ralph, S.J.
    Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells.
    Molecular Nutrition & Food Research. Roč. 55, č. 10 (2011), s. 1543-1551 ISSN 1613-4125
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: Vitamin E analogues * mitochondrial complex II * modelling
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 4.301, rok: 2011

    Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.
    Trvalý link: http://hdl.handle.net/11104/0203545