Počet záznamů: 1

Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

  1. 1.
    0369494 - BTO-N 2012 RIV US eng J - Článek v odborném periodiku
    Ralph, S.J. - Moreno-Sanchez, R. - Neužil, Jiří - Rodriguez-Enriquez, S.
    Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death.
    Pharmaceutical Research. Roč. 28, č. 11 (2011), s. 2695-2730 ISSN 0724-8741
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: Mitocans * SDH/Complex II * mitochondrial ROS production
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 4.093, rok: 2011

    Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies.
    Trvalý link: http://hdl.handle.net/11104/0006745