Počet záznamů: 1

Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal

  1. 1.
    0369475 - FGU-C 2012 RIV NL eng J - Článek v odborném periodiku
    Ujčíková, Hana - Dlouhá, Kateřina - Roubalová, Lenka - Vošahlíková, Miroslava - Kagan, Dmytro - Svoboda, Petr
    Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.
    Biochimica et Biophysica Acta. General Subjects. Roč. 1810, č. 12 (2011), s. 1220-1229 ISSN 0304-4165
    Grant CEP: GA MŠk(CZ) LC554; GA MŠk(CZ) LC06063; GA ČR(CZ) GD305/08/H037
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: morphine * long-term adaptation * adenylyl cyclase isoforms I–IX * forebrain cortex * isolated plasma membranes
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 5.000, rok: 2011

    We assume that the specific increase in expression level of ACI and ACII in brain cortex of morphine-adapted rats proceeds as a compensatory, homeostatic response to prolonged exposure to inhibitory drug, morphine. Our findings demonstrate that the dramatic and specific change of the crucial component of the opioid receptor cascade in brain cortex, manifested as an increase in PM level of ACI and II, is reversible
    Trvalý link: http://hdl.handle.net/11104/0203528