Počet záznamů: 1

Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates

  1. 1.
    0369214 - UOCHB-X 2012 RIV CZ eng J - Článek v odborném periodiku
    Jansa, Petr - Kolman, Viktor - Kostinová, Alexandra - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
    Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates.
    Collection of Czechoslovak Chemical Communications. Roč. 76, č. 10 (2011), s. 1187-1198 ISSN 0010-0765
    Grant CEP: GA MV VG20102015046
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: nucleosides * nucleotides * phosphorus * fluorine * biological activity * antibiotics
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.283, rok: 2011

    Efficient synthesis of acyclic nucleosides and acyclic nucleoside phosphonates substituted at the C-2′ position of the aliphatic part by the trifluoromethyl group is described, starting from trifluoromethyloxirane. None of the prepared compounds exhibit any antiviral, antiproliferative or anti-toxin activities.
    Trvalý link: http://hdl.handle.net/11104/0203334