Počet záznamů: 1

Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor

  1. 1.
    0369138 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Jindřichová, Marie - Khafizov, K. - Skorinkin, A. - Fayuk, D. - Bart, G. - Zemková, Hana - Giniatullin, R.
    Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.
    Journal of Neurochemistry. Roč. 119, č. 4 (2011), s. 676-685 ISSN 0022-3042
    Grant CEP: GA AV ČR(CZ) IAA500110910
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: purinergic receptors * desensitization * patch clamp
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.061, rok: 2011

    Purinergic P2X receptors are ubiquitous, ligand-gated cationic channels activated by extracellular ATP. The P2X3 receptors, which are involved in nociception, are known for their very fast and complete desensitization, which persists for many minutes. Structural modeling followed by experimental validation of predictions suggested conserved tyrosine 37side chain is needed for the stabilization of the closed receptor state while kinetic modeling specifies that lack of Y37 results in destabilization of closed desensitized states
    Trvalý link: http://hdl.handle.net/11104/0203279