Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]

0368775 - BFÚ 2012 RIV US eng J - Článek v odborném periodiku
Westendorf, A.F. - Zerzánková, Lenka - Salassa, L. - Sadler, P.J. - Brabec, Viktor - Bednarski, P.J.
Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)].
Journal of Inorganic Biochemistry. Roč. 105, č. 5 (2011), s. 652-662. ISSN 0162-0134. E-ISSN 1873-3344
Grant CEP: GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GD301/09/H004; GA ČR(CZ) GAP301/10/0598
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: platinum azides * cisplatin * photoactivation
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.354, rok: 2011

The photocytotoxicity and photobiochemical properties of the new complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)(piperidine)] are compared with its analogue containing the less basic and less lipophilic ligand pyridine. The results indicate that the piperidine complex has a more rapid rate of light activation to cytotoxic species but in other cellular and biochemical aspects its behavior is similar to that of pyridine analogue.
Trvalý link: http://hdl.handle.net/11104/0203023