Počet záznamů: 1

Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

  1. 1.
    0368757 - BFU-R 2012 RIV IE eng J - Článek v odborném periodiku
    Hrubá, E. - Vondráček, Jan - Líbalová, Helena - Topinka, Jan - Bryja, Vítězslav - Souček, Karel - Machala, M.
    Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands.
    Toxicology Letters. Roč. 206, č. 2 (2011), s. 178-188 ISSN 0378-4274
    Grant CEP: GA ČR(CZ) GA310/07/0961; GA ČR(CZ) GA524/09/1337
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
    Klíčová slova: LNCaP cells * AhR ligands * WNT5A
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.230, rok: 2011

    The results of the present study showed that effects of model genotoxic and nongenotoxic AhR ligands on global changes in gene expression in LNCaP cells significantly overlap, thus suggesting that the activation of AhR plays a prominent role in the nongenotoxic effects of BaP in the prostate carcinoma cell model. We identified Wnt5a, an important regulator of prostate cancer progression, to be induced after exposure to both AhR ligands, which may further contribute to enhanced cell plasticity of prostate carcinoma cells.
    Trvalý link: http://hdl.handle.net/11104/0203013