Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study

0368688 - ÚEM 2012 RIV GB eng J - Článek v odborném periodiku
Noristani, H. N. - Meadows, R. S. - Olabarria, M. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study.
Cell Death & Disease. Roč. 2, - (2011), e210. ISSN 2041-4889. E-ISSN 2041-4889
Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384; GA ČR(CZ) GAP304/11/0184; GA ČR GA309/08/1381
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Alzheimer's disease * serotonin * serotonin transporter
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 5.333, rok: 2011

Here, we analysed the ultrastructural localisation, distribution and numerical density of hippocampal SERT axons (SERT-Ax) and terminals (SERT-Te) and their relationship with SERT fibre sprouting and altered synaptic density in 3xTg-AD compared with non-transgenic control mice. Our results suggested that concomitant increase in density of serotonergic terminals and reduction in the number of perforated axospinous synapses in 3xTg-AD mice (a model of Alzheimer’s disease) may act as a compensatory mechanism maintaining synaptic efficacy as a response to the AD cognitive impairment.
Trvalý link: http://hdl.handle.net/11104/0202966