Počet záznamů: 1

Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study

  1. 1.
    0368688 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Noristani, H. N. - Meadows, R. S. - Olabarria, M. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
    Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study.
    Cell Death & Disease. Roč. 2, - (2011), e210 ISSN 2041-4889
    Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384; GA ČR(CZ) GAP304/11/0184; GA ČR GA309/08/1381
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: Alzheimer's disease * serotonin * serotonin transporter
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 5.333, rok: 2011

    Here, we analysed the ultrastructural localisation, distribution and numerical density of hippocampal SERT axons (SERT-Ax) and terminals (SERT-Te) and their relationship with SERT fibre sprouting and altered synaptic density in 3xTg-AD compared with non-transgenic control mice. Our results suggested that concomitant increase in density of serotonergic terminals and reduction in the number of perforated axospinous synapses in 3xTg-AD mice (a model of Alzheimer’s disease) may act as a compensatory mechanism maintaining synaptic efficacy as a response to the AD cognitive impairment.
    Trvalý link: http://hdl.handle.net/11104/0202966