Počet záznamů: 1

Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression

  1. 1.
    0368653 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Gábelová, A. - Valovičová, Z. - Mesárošová, M. - Trilecová, L. - Hrubá, E. - Marvanová, S. - Krčmář, P. - Milcová, Alena - Schmuczerová, Jana - Vondráček, J. - Machala, M. - Topinka, Jan
    Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.
    Environmental and Molecular Mutagenesis. Roč. 52, č. 8 (2011), s. 636-645 ISSN 0893-6692
    Grant CEP: GA MŠk(CZ) 2B08005
    Grant ostatní: GA MZE(CZ) MZE0002716202
    Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50040702; CEZ:AV0Z50040507
    Klíčová slova: dibenzo[c,g]carbazoles * DNA strand breaks * DNA adducts
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.709, rok: 2011

    The goal of this study was to investigate the genotoxicity of dibenzocarbazoles in human hepatoma HepG2 cells and to infer potential mechanisms underlying the biological activity of particular carcinogen. All dibenzocarbazoles, regardless the tissue specificity, induced significant DNA strand break levels and micronuclei in HepG2 cells; though a mitotic spindle dysfunction rather than a chromosome breakage was implicated in N-MeDBC-mediated micronucleus formation. Our data clearly demonstrated differences in the mechanisms involved in the biological activity of DiMeDBC and N-MeDBC in human hepatoma cells; the genotoxicity of these DBC derivatives is closely related to CYP1A1/2 expression.
    Trvalý link: http://hdl.handle.net/11104/0202943