Počet záznamů: 1

Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes

  1. 1.
    0368636 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Řehoř, I. - Vilímová, V. - Jendelová, Pavla - Kubíček, V. - Jirák, D. - Herynek, V. - Kapcalová, Miroslava - Kotek, J. - Černý, J. - Hermann, P. - Lukeš, I.
    Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes.
    Journal of Medicinal Chemistry. Roč. 54, č. 14 (2011), s. 5185-5194 ISSN 0022-2623
    Grant ostatní:GA MŠk(CZ) OC 179; GA MŠk(CZ) COST D38
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: MRI contrast agent * stem-cell therapy * Ti02 particles
    Kód oboru RIV: CA - Anorganická chemie
    Impakt faktor: 5.248, rok: 2011

    Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high 1H relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MRI. Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy.
    Trvalý link: http://hdl.handle.net/11104/0202928