Počet záznamů: 1

Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1

  1. 1.
    0368598 - UEB-Q 2012 RIV US eng J - Článek v odborném periodiku
    Maj, J. - Morzycki, J.W. - Rárová, Lucie - Oklešťková, Jana - Strnad, Miroslav - Wojtkielewicz, A.
    Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1.
    Journal of Medicinal Chemistry. Roč. 54, č. 9 (2011), s. 3298-3305 ISSN 0022-2623
    Grant CEP: GA ČR GA301/08/1649; GA MŠk ED0007/01/01
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: POTENT ANTITUMOR SAPONIN * CHOLESTANE GLYCOSIDES * ORNITHOGALUM-SAUNDERSIAE * SIDE-CHAINS * AGLYCONE
    Kód oboru RIV: EF - Botanika
    Impakt faktor: 5.248, rok: 2011

    Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
    Trvalý link: http://hdl.handle.net/11104/0202897