Počet záznamů: 1

MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic

  1. 1.
    0367822 - UEM-P 2012 RIV NL eng J - Článek v odborném periodiku
    Pardini, Barbara - Kumar, R. - Naccarati, Alessio - Prasad, R. B. - Försti, A. - Poláková, Veronika - Vodičková, Ludmila - Novotný, J. - Hemminki, K. - Vodička, Pavel
    MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Roč. 721, č. 1 (2011), s. 74-80 ISSN 1383-5718
    Grant CEP: GA ČR GP305/09/P194; GA ČR GAP304/10/1286; GA MZd NS10230
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Colorectal cancer risk * MTHFR * MTRR
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.035, rok: 2011

    Polymorphic variants in genes involved in metabolisms of dietary folate may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR and MTRR genes with the risk for colorectal cancer in the Czech Republic. We have concluded that the 677TT genotype and the TA haplotype in the MTHFR gene may also play a role in colorectal cancer risk in the Czech population. No difference in the distribution between cases and controls was observed for the haplotypes based on the four polymorphisms in the MTRR gene.
    Trvalý link: http://hdl.handle.net/11104/0202368