Počet záznamů: 1

5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

  1. 1.
    0367817 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Pardini, Barbara - Kumar, R. - Naccarati, Alessio - Prasad, R. B. - Försti, A. - Hemminki, K. - Vodička, Pavel - Bermejo, J. L.
    5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.
    British Journal of Clinical Pharmacology. Roč. 72, č. 1 (2011), s. 162-163 ISSN 0306-5251
    Grant CEP: GA ČR GAP304/10/1286; GA ČR GP305/09/P194
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: fluorouracil * DNA-damage * nepolymorphisms
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.958, rok: 2011

    Treatment with 5-fluorouracil is known to improve survival in various cancers, mainly in colorectal cancer. Crucial metabolite of 5 FU depends on methylene-tetrahydro-folate reductase, MTHFR. We investigated 6 genetic variants in the MTHFR and MTRR genes on the clinical outcome of 273 patients treated by 5FU. One variant in MTHFR gene showed association with progression-free survival in heterozygotes and homozygotes bearers and is connected with statistically significant better survival. None of other investigated variants showed any association with the survival.
    Trvalý link: http://hdl.handle.net/11104/0202364