Počet záznamů: 1

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

  1. 1.
    0367814 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Winkelmann, J. - Czamara, D. - Schormair, B. - Knauf, F. - Schulte, E. C. - Vodička, Pavel
    Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1.
    PLoS Genetics. Roč. 7, č. 7 (2011), e1002171 ISSN 1553-7390
    Grant CEP: GA MZd NR8563
    Grant ostatní: GA MŠk(CZ) MSM0021620849; GA MŠk(CZ) MSM0021620816
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: TOX3 * transcription * common genetic-variants
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.694, rok: 2011

    Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age, which severely harms life comfort and working ability. We conducted a genome-wide association study (GWA) for RLS in 922 cases and 1,526 controls (using 301,406 SNPs) followed by a replication of 76 candidate SNPs in 3,935 cases and 5,754 controls, all of European ancestry. We identified several susceptibility loci, two of them novel.
    Trvalý link: http://hdl.handle.net/11104/0202361