Počet záznamů: 1

DNA damage and nucleotide excision repair capacity in healthy individuals

  1. 1.
    0367811 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Slyšková, Jana - Naccarati, Alessio - Poláková, Veronika - Pardini, Barbara - Vodičková, Ludmila - Štětina, R. - Schmuczerová, Jana - Šmerhovský, Z. - Lipská, L. - Vodička, Pavel
    DNA damage and nucleotide excision repair capacity in healthy individuals.
    Environmental and Molecular Mutagenesis. Roč. 25, č. 7 (2011), s. 511-517 ISSN 0893-6692
    Grant CEP: GA ČR GAP304/10/1286; GA MŠk 7F10069
    Grant ostatní: GA MŠk(CZ) GAUK124710
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: BPDE-induced DNA repair capacity * comet assay * interindividual variability
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.709, rok: 2011

    Interindividual differences in DNA repair capacity (DRC) represent an important source of variability in genome integrity and thus influence health risk. DRC represents as well a potential biomarker in cancer prediction. The ultimate goal of our study was to obtain reference data from cancer-free population, e.g. background level for further investigations on cancer patients. Endogenous damage and DRC, specific for nucleotide excision repair (NER), was evaluated using modified comet assay and using challenge assay, genetic polymorphisms in NER genes were assessed as well. DNA damage and DRC exerted substantial interindividual variability, were associated with several confounders and modulated by particular genotypes of NER genes.
    Trvalý link: http://hdl.handle.net/11104/0202358