Počet záznamů: 1
DNA damage and nucleotide excision repair capacity in healthy individuals
0367811 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
Slyšková, Jana - Naccarati, Alessio - Poláková, Veronika - Pardini, Barbara - Vodičková, Ludmila - Štětina, R. - Schmuczerová, Jana - Šmerhovský, Z. - Lipská, L. - Vodička, Pavel
DNA damage and nucleotide excision repair capacity in healthy individuals.
Environmental and Molecular Mutagenesis. Roč. 25, č. 7 (2011), s. 511-517 ISSN 0893-6692
Grant CEP: GA ČR GAP304/10/1286; GA MŠk 7F10069
Grant ostatní:GA MŠk(CZ) GAUK124710
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: BPDE-induced DNA repair capacity * comet assay * interindividual variability
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.709, rok: 2011
Interindividual differences in DNA repair capacity (DRC) represent an important source of variability in genome integrity and thus influence health risk. DRC represents as well a potential biomarker in cancer prediction. The ultimate goal of our study was to obtain reference data from cancer-free population, e.g. background level for further investigations on cancer patients. Endogenous damage and DRC, specific for nucleotide excision repair (NER), was evaluated using modified comet assay and using challenge assay, genetic polymorphisms in NER genes were assessed as well. DNA damage and DRC exerted substantial interindividual variability, were associated with several confounders and modulated by particular genotypes of NER genes.
Trvalý link: http://hdl.handle.net/11104/0202358