Počet záznamů: 1

Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

  1. 1.
    0367668 - UEB-Q 2012 RIV US eng J - Článek v odborném periodiku
    Hošek, J. - Bartoš, M. - Chudík, S. - Dall’Acqua, S. - Innocenti, G. - Kartal, M. - Kokoška, L. - Kollár, P. - Kutil, Zsófia - Landa, Přemysl - Marek, R. - Závalová, V. - Žemlička, M. - Šmejkal, K.
    Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro.
    Journal of Natural Products. Roč. 74, č. 4 (2011), s. 614-619 ISSN 0163-3864
    Grant CEP: GA MŠk(CZ) LC06030; GA ČR GP525/09/P528
    Výzkumný záměr: CEZ:AV0Z50380511
    Kód oboru RIV: GM - Potravinářství
    Impakt faktor: 3.128, rok: 2011

    Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead.
    Trvalý link: http://hdl.handle.net/11104/0202261