Počet záznamů: 1

Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties

  1. 1.
    0367626 - UOCHB-X 2012 RIV US eng J - Článek v odborném periodiku
    Rejman, Dominik - Rabatinová, Alžběta - Pombinho, António R. - Kovačková, Soňa - Pohl, Radek - Zborníková, Eva - Kolář, M. - Bogdanová, K. - Nyč, O. - Šanderová, Hana - Látal, T. - Bartůněk, Petr - Krásný, Libor
    Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties.
    Journal of Medicinal Chemistry. Roč. 54, č. 22 (2011), s. 7884-7898 ISSN 0022-2623
    Grant CEP: GA MŠk(CZ) LC06077; GA ČR GA204/09/0583; GA ČR GAP302/11/0855; GA MŠk 2B06065
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50200510; CEZ:AV0Z50520514
    Klíčová slova: lipofosfonoxin * antibacterial * nucleoside
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 5.248, rok: 2011

    Novel compounds termed lipophosphonoxins were prepared using a simple and efficient synthetic approach. The general structure of lipophosphonoxins consists of four modules: (i) a nucleoside module, (ii) an iminosugar module, (iii) a hydrophobic module (lipophilic alkyl chain), and (iv) a phosphonate linker module that holds together modules i–iii. Lipophosphonoxins displayed significant antibacterial properties against a panel of Gram-positive species, including multiresistant strains. The minimum inhibitory concentration (MIC) values of the best inhibitors were in the 1–12 .mu.g/mL range, while their cytotoxic concentrations against human cell lines were significantly above this range. The modular nature of this artificial scaffold offers a large number of possibilities for further modifications/exploitation of these compounds.
    Trvalý link: http://hdl.handle.net/11104/0202228