Počet záznamů: 1

Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks

  1. 1.
    0367428 - MBU-M 2012 RIV US eng J - Článek v odborném periodiku
    Vohradská, E. - Vohradský, Jiří
    Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks.
    PLoS ONE. Roč. 6, č. 4 (2011), s. 1-9 E-ISSN 1932-6203
    Grant CEP: GA ČR GA310/07/1009; GA ČR GAP302/11/0229
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: REGULATORY NETWORKS * SACCHAROMYCES-CEREVISIAE * CELL-CYCLE
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 4.092, rok: 2011

    Study of genetic networks has moved from qualitative description of interactions between regulators and regulated genes to the analysis of the interaction dynamics. This paper focuses on the analysis of dynamics of one particular network – the yeast cyclins network. Using a dedicated mathematical model of gene expression and a procedure for computation of the parameters of the model from experimental data, a complete numerical model of the dynamics of the cyclins genetic network was attained. The model allowed for performing virtual experiments on the network and observing their influence on the expression dynamics of the genes downstream in the regulatory cascade. Results show that when the network structure is more complicated, and the regulatory interactions are indirect, results of gene deletion are highly unpredictable
    Trvalý link: http://hdl.handle.net/11104/0202124