Počet záznamů: 1

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat

  1. 1.
    0367313 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Morrissey, C. - Grieve, I. - Heinig, M. - Atanur, S. - Petretto, E. - Pravenec, Michal - Hubner, N. - Aitman, T. J.
    Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
    Physiological Genomics. Roč. 43, č. 21 (2011), s. 1207-1218 ISSN 1094-8341
    Grant CEP: GA ČR(CZ) GA301/08/0166; GA MŠk(CZ) ME10019
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: eQTL * spontaneously hypertensive rat * quantitative trait transcript * sequence variation
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.735, rok: 2011

    The Spontaneously Hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. By integration of genomic sequence, eQTL and QTT datasets we have identified several genes that are strong positional candidates for pathophysiological traits observed in the SHR strain. These findings provide a basis for the functional testing and ultimate elucidation of the molecular basis of these metabolic and cardiovascular phenotypes
    Trvalý link: http://hdl.handle.net/11104/0202044