Počet záznamů: 1

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

  1. 1.
    0367248 - BC-A 2012 RIV US eng J - Článek v odborném periodiku
    Lake, A.D. - Novák, Petr - Fisher, C.D. - Jackson, J.P. - Hardwick, R.N. - Billheimer, D.D. - Klimecki, W.T. - Cherrington, N.J.
    Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease.
    Drug Metabolism and Disposition. Roč. 39, č. 10 (2011), s. 1954-1960 ISSN 0090-9556
    Výzkumný záměr: CEZ:AV0Z50510513
    Klíčová slova: Steatosis * Steatohepatitis * Nonalcoholic fatty liver disease
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.733, rok: 2011

    Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The objective of this study is to describe changes in global gene expression associated with the progression of human NAFLD. This study is focused on the expression levels of genes responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs. Differential gene expression between three clinically defined pathological groups-normal, steatosis, and NASH-was analyzed.The results suggest that uptake transporter genes are coordinately targeted for down-regulation at the global level during the pathological development of NASH and that these patients may have decreased drug uptake capacity. This coordinated regulation of uptake transporter genes is indicative of a hepatoprotective mechanism acting to prevent accumulation of toxic intermediates in disease-compromised hepatocytes.
    Trvalý link: http://hdl.handle.net/11104/0201992