Počet záznamů: 1

Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair

  1. 1.
    0367041 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Kostrhunová, Hana - Malina, Jaroslav - Pickard, A.J. - Štěpánková, Jana - Vojtíšková, Marie - Kašpárková, Jana - Muchová, T. - Rohlfing, M.L. - Bierbach, U. - Brabec, Viktor
    Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.
    MOLECULAR PHARMACEUTICS. Roč. 8, č. 5 (2011), s. 1941-1954 ISSN 1543-8384
    Grant CEP: GA ČR(CZ) GAP205/11/0856
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: platinum * DNA binding * anticancer effects
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.782, rok: 2011

    A combination of biophysical, biochemical, and computational techniques was used to delineate mechanistic differences between the platinum-acridine hybrid agent [PtCl(en)(L)]NO3)2 (en = ethane-1,2-diamine, L = 1-[acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) and a considerably more potent second-generation analogue containing L = N-[2-(acridin-9-ylamino)ethyl]-N-methylpropionamidine.
    Trvalý link: http://hdl.handle.net/11104/0006656