The diffusion parameters of the extracellular space are altered in focal cortical dysplasias

0366716 - ÚEM 2012 RIV IE eng J - Článek v odborném periodiku
Vargová, Lýdia - Homola, Aleš - Cicanič, Michal - Kuncová, K. - Kršek, P. - Marusič, P. - Syková, Eva - Zámečník, J.
The diffusion parameters of the extracellular space are altered in focal cortical dysplasias.
Neuroscience Letters. Roč. 499, č. 1 (2011), s. 19-23. ISSN 0304-3940. E-ISSN 1872-7972
Grant ostatní: GA MZO(CZ) NS9915
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: epilepsy * focal cortical dysplasia * extracellular diffusion
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.105, rok: 2011

The ECS diffusion parameters were determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients and correlated with the histologicaly assessed type of cortical dysplasia (FCD type I or II). While the extracellular volume remained unchanged (FCD I) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion in dysplastic tissue.
Trvalý link: http://hdl.handle.net/11104/0201605