Počet záznamů: 1

Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases

  1. 1.
    0366631 - MBU-M 2012 RIV GB eng J - Článek v odborném periodiku
    Jančová, P. - Šiller, M. - Anzenbacherová, E. - Křen, Vladimír - Anzenbacher, P. - Šimánek, V.
    Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.
    Xenobiotica. Roč. 41, č. 9 (2011), s. 743-751 ISSN 0049-8254
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Silybin * conjugation * metabolism
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 1.791, rok: 2011

    The flavonolignan silybin, the main component of silymarin, extract from the seeds of Silybum marianum, is used mostly as a hepatoprotectant. Silybin is almost 1:1 mixture of two diastereomers A and B. The individual UDP-glucuronosyltransferases (UGTs) contributing to the metabolism of silybin diastereomers have not been identified yet. In this study, the contribution of UGTs to silybin metabolism was examined
    Trvalý link: http://hdl.handle.net/11104/0201545