Počet záznamů: 1

Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2

  1. 1.
    0366527 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Pernicová, Zuzana - Slabáková, Eva - Kharaishvili, G. - Bouchal, J. - Král, M. - Kunická, Z. - Machala, M. - Kozubík, Alois - Souček, Karel
    Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
    Neoplasia. Roč. 13, č. 6 (2011), s. 526-536 ISSN 1522-8002
    Grant CEP: GA ČR(CZ) GA310/07/0961; GA MZd NS9600; GA MZd NS9956
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: prostate cancer * senescence * Skp2
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.946, rok: 2011

    Here we show that androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces senescence-associated secretory phenotype together with neuroendocrine differentiation in prostate cancer cells. The induction of senescent phenotype was at least in part mediated by down-regulation of Skp2, while neuroendocrine differentiation was under separate control. Induction of senescence may therefore contribute to development of androgen independence in response to androgen deprivation therapy.
    Trvalý link: http://hdl.handle.net/11104/0201494