Počet záznamů: 1

TGF-beta1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNA12/slug

  1. 1.
    0366426 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Slabáková, Eva - Pernicová, Zuzana - Slavíčková, Eva - Staršíchová, Andrea - Kozubík, Alois - Souček, Karel
    TGF-beta1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNA12/slug.
    Prostate. Roč. 71, č. 12 (2011), s. 1332-1343 ISSN 0270-4137
    Grant CEP: GA ČR(CZ) GA310/07/0961; GA ČR(CZ) GD303/09/H048; GA MZd NS9600; GA MZd NS9956
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: epithelial-mesenchymal transition * SNAI2/Slug * transforming growth factor-beta1
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.485, rok: 2011

    Epithelial-mesenchymal transition (EMT) is involved in physiological processes ranging from embryonic development to tissue remodeling, regeneration, organ fibrosis, cancer progression and metastasis. In this study, we focus on the kinetics of expression of EMT markers and both transcription factors and miRNAs regulating the EMT process in the BPH-1 cell line and in tumorigenic clones derived from this cell line. To the best of our knowledge, this is the first detailed description of EMT regulation in a non-transformed, immortalized epithelial cell line of prostate origin.
    Trvalý link: http://hdl.handle.net/11104/0201427