Počet záznamů: 1

Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA

  1. 1.
    0366267 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Mládek, Arnošt - Šponer, Jiří - Sumpter, B.G. - Fuentes-Cabrera, M. - Šponer, Judit E.
    Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA.
    Physical Chemistry Chemical Physics. Roč. 13, č. 23 (2011), s. 10869-10871 ISSN 1463-9076
    Grant CEP: GA MŠk(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GAP208/10/2302; GA ČR(CZ) GA203/09/1476; GA ČR(CZ) GAP208/11/1822; GA ČR(CZ) GD203/09/H046
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: quantum chemistry * prebiotic chemistry * As-DNA
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.573, rok: 2011

    Quantum chemical calculations reveal that neither sterin hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.
    Trvalý link: http://hdl.handle.net/11104/0201320