Počet záznamů: 1

Glycosidases in Synthesis of Glycomimetics and Unnatural Carbohydrates

  1. 1.
    0366245 - MBU-M 2012 RIV GB eng M - Část monografie knihy
    Křen, Vladimír
    Glycosidases in Synthesis of Glycomimetics and Unnatural Carbohydrates.
    Synthesis and Biological Applications of Glycoconjugates. Velká Británie: Bentham Science Publishers Ltd, 2011 - (Renaudet, O.; Spinelli, N.), s. 226-239. ISBN 978-1-60805-277-6
    Grant CEP: GA MŠk(CZ) LC06010
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: glycosidase * glycosynthase * thioglycoligase
    Kód oboru RIV: CC - Organická chemie

    In recent years, carbohydrate-processing enzymes have become the enzymes of choice in many applications thanks to their stereoselectivity and efficiency. This chapter presents recent development in glycosidase-catalyzed synthesis of unnatural semisynthetic carbohydrate structures via two complementary approaches: the use of wild-type enzymes with engineered substrates and mutant glycosidases. Genetic engineering has recently produced glucuronyl synthases, an inverting xylosynthase and the first mutant endo-β-N-acetylglucosaminidase
    Trvalý link: http://hdl.handle.net/11104/0201299