Počet záznamů: 1

Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases

  1. 1.
    0366242 - MBU-M 2012 RIV DE eng J - Článek v odborném periodiku
    Rech, C. - Rosencrantz, R. R. - Křenek, Karel - Pelantová, Helena - Bojarová, Pavla - Roemer, Ch. E. - Hanisch, F.-G. - Křen, Vladimír - Elling, L.
    Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases.
    Advanced Synthesis & Catalysis. Roč. 353, č. 13 (2011), s. 2492-2500 ISSN 1615-4150
    Grant CEP: GA MŠk OC09045
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: combinatorial chemistry * biocatalysis * carbohydrates
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 6.048, rok: 2011

    Poly-N-acetyllactosamine (Poly-LacNAc, [3Galβ1,4GlcNAcβ1]n) glycans play an Essentials role in carbohydrate-protein interactions. The synthesis of poly-LacNAc, both chemical and enzymatic, is typically characterized by high losses of product during sequential synthesis, due to deprotection and/ or purification steps. In this work we present a onepot synthesis of poly-LacNAc oligosaccharides by combining recombinant glycosyltransferases
    Trvalý link: http://hdl.handle.net/11104/0201297