Počet záznamů: 1

Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

  1. 1.
    0366149 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Mikeš, J. - Hýžďalová, Martina - Kočí, Lenka - Jendželovský, R. - Koval, J. - Vaculová, Alena - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, P.
    Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
    Photochemical & Photobiological Sciences. Roč. 10, č. 4 (2011), s. 626-632 ISSN 1474-905X
    Grant CEP: GA ČR(CZ) GA301/07/1557
    Grant ostatní: GA ČR(CZ) GA305/09/1526
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: photodynamic therapy * hypericin * colon cancer
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.584, rok: 2011

    Hypericin (HY) has found applications in photodynamic diagnostics solely due to its high specificity for tumour cells and tissues. We showed that despite the higher accumulation of HY in FHC human fetal colon epithelial cells compared to HT-29 colon adenocarcinoma cells, the cytotoxic effects of this photosensitizer were more pronounced in the latter cell line, and this was associated with enhanced accumulation of HY-induced reactive oxygen species (ROS).
    Trvalý link: http://hdl.handle.net/11104/0201224