Počet záznamů: 1

Interferon-inducible protein 16: Insight into the interaction with tumor suppressor p53

  1. 1.
    0366123 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Liao, J.C.C. - Lam, R. - Brázda, Václav - Duan, S. - Ravichandran, M. - Ma, J. - Xiao, T. - Tempel, W. - Zuo, X. - Wang, Y.-X. - Chirgadze, N.Y. - Arrowsmith, Ch.H.
    Interferon-inducible protein 16: Insight into the interaction with tumor suppressor p53.
    Structure. Roč. 19, č. 3 (2011), s. 418-424 ISSN 0969-2126
    Grant CEP: GA ČR(CZ) GAP301/10/1211
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: p53 * HIN domain * p53-DNA complex
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 6.347, rok: 2011

    Here, we report the crystal structures of both HIN-A and HIN-B domains of IFI16 determined at 2.0 and 2.35 Ao resolution, respectively. We show that both HIN domains of IFI16 are capable of enhancing p53-DNA complex formation and transcriptional activation via distinctive means.
    Trvalý link: http://hdl.handle.net/11104/0201205