Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice

0366099 - ÚOCHB 2012 RIV GB eng J - Článek v odborném periodiku
Pirnik, Z. - Bundziková, J. - Holubová, Martina - Pýchová, Miroslava - Fehrentz, J. A. - Martinez, J. - Železná, Blanka - Maletínská, Lenka - Kiss, A.
Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice.
Neurochemistry International. Roč. 59, č. 6 (2011), s. 889-895. ISSN 0197-0186. E-ISSN 1872-9754
Grant CEP: GA ČR GA303/09/0744
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: ghrelin agonists * Fos immunohistochemistry * male C57BL/6 mice
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.857, rok: 2011

Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable analogues, agonists: Dpr3ghr ([Dpr(N-octanoyl)3] ghrelin) (Dpr – diaminopropionic acid), YA GHRP-6 (Tyr-Ala-His-DTrp-Ala-Trp-DPhe-Lys-NH2), and JMV1843 (H-Aib-DTrp-D-gTrp-CHO) on the Fos expression in food intake-responsive brain areas such as the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei, the nucleus of the solitary tract (NTS), and area postrena (AP) in male C57BL/6 mice. Immunohistochemical analysis showed that acute SC administration of each of these substances, in dose (5 mg/kg b.w.), which induce strong food intake increase, elevated Fos protein expression in all brain areas studied.
Trvalý link: http://hdl.handle.net/11104/0201186