Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury

0366090 - ÚEM 2012 RIV US eng J - Článek v odborném periodiku
Arboleda Toro, David - Forostyak, Serhiy - Jendelová, Pavla - Mareková, Dana - Amemori, Takashi - Pivoňková, Helena - Mašínová, Katarína - Syková, Eva
Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury.
Cellular and Molecular Neurobiology. Roč. 31, č. 7 (2011), s. 1113-1122. ISSN 0272-4340. E-ISSN 1573-6830
Grant CEP: GA ČR GA305/09/0717; GA AV ČR IAA500390902
Grant ostatní: GA MŠk.(CZ) 1M0538; GA ČR(CZ) GD309/08/H079; GA ČR(CZ) GAP304/10/0320
Program: 1M
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Klíčová slova: Adipose tissue * Differentiation * Mesenchymal stromal cells
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.969, rok: 2011

The purpose of the study was to compare predifferentiated ASCs (pASCs) with naïve ASCs in vitro and after transplantation into rats with a balloon-induced spinal cord compression lesion. ASC spheres were induced prior to transplantation, then pASCs or ASCs were injected intraspinally. Behavioral, histological and electrophysiological methods were used to assess the cells' fate and the rats' functional outcome.The predifferentiation of ASCs facilitated the protection of denuded axons; however, functional improvement was comparable in both groups, indicating that repair was induced mainly through paracrine mechanisms.
Trvalý link: http://hdl.handle.net/11104/0201181