Počet záznamů: 1

Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial

  1. 1.
    0366082 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Kočí, Lenka - Hýžďalová, Martina - Vaculová, Alena - Hofmanová, Jiřina - Kozubík, Alois
    Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial.
    Cytokine. Roč. 55, č. 1 (2011), s. 34-39 ISSN 1043-4666
    Grant CEP: GA ČR(CZ) GA524/07/1178; GA ČR(CZ) GA301/07/1557; GA ČR(CZ) GD303/09/H048; GA ČR(CZ) GA305/09/1526
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: TRAIL * anoikis * PI3K/Akt pathway
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.019, rok: 2011

    The resistance of transformed epithelial cells to a detachment-induced apoptosis (anoikis) can significantly affect their susceptibility to anticancer therapy. We showed that detachment of both fetal (FHC) and adenocarcinoma (HT-29) human colon epithelial cells resulted in the activation of the pro-survival Akt pathway, and significant changes in integrin-linked kinase (ILK) and focal adhesive kinase (FAK) phosphorylation. Our results may have important implications for optimization of new strategies in treatment of cancers at different stages of development.
    Trvalý link: http://hdl.handle.net/11104/0201173