Počet záznamů: 1

Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

  1. 1.
    0365887 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Cang, X. - Šponer, Jiří - Cheatham III, T.E.
    Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes.
    Nucleic Acids Research. Roč. 39, č. 10 (2011), s. 4499-4512 ISSN 0305-1048
    Grant CEP: GA MŠk(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: quantum chemistry * DNA * quadruplex
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 8.026, rok: 2011

    Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn.
    Trvalý link: http://hdl.handle.net/11104/0201027