Počet záznamů: 1

Thermoresponsive micelles for radionuclide delivery

  1. 1.
    0365874 - UMCH-V 2012 RIV NL eng J - Článek v odborném periodiku
    Hrubý, Martin - Filippov, Sergey K. - Pánek, Jiří - Nováková, Michaela - Macková, Hana - Kučka, Jan - Ulbrich, Karel
    Thermoresponsive micelles for radionuclide delivery.
    Journal of Controlled Release. Roč. 148, č. 1 (2010), e60-e62 ISSN 0168-3659.
    [European Symposium on Controlled Drug Delivery /11./. Egmond aan Zee, 07.04.2010-09.04.2010]
    Grant CEP: GA AV ČR KAN200200651; GA MŠk 1M0505; GA ČR GPP207/10/P054
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: micelles * drug delivery systems * thermoresponsive polymers
    Kód oboru RIV: FR - Farmakologie a lékárnická chemie
    Impakt faktor: 7.164, rok: 2010

    We have synthesized and characterized a thermoresponsive micellar radionuclide delivery system based on ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous milieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter ~ 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions.
    Trvalý link: http://hdl.handle.net/11104/0201017